In summary, in this research paper several microemulsion-based hydrogels were developed and evaluated for their potential as topical delivery systems for Lornoxicam, a hydrophobic drug presenting extensive first-pass metabolism and short elimination half-life after oral administration, and also poor aqueous solubility. The results showed that the content of microemulsion based hydrogels components (oil, Smix and water) had significant effect on their physical, rheological and in vitro drug release characteristics. It were considered as most desirable formulations the microemulsion-based hydrogels containing eutectic mixture [Camphor (5%) and menthol (5%) respectively] as oil phase, Smix (2:1) Tween 80 Ethanol (30%) as surfactant-cosurfactant, Carbopol 934p (1.5%) as gelling agent. since they exhibited high flux value (3.91 μg/cm2/hr), highest release rate values (78.91%), good spreadability values (5.89 g.cm/sec). The formulations also possessed the globule size of 175.7 nm, the polidispersity index of 0.289 and zeta potential of -21.4 mV respectively. Carrageenan induced paw edema tests revealed anti inflammatory and analgesic activity. The formulations F1 and F4 were comparable with marketed topical gel. So lornoxicam hydrolgel can be used as an anti-inflammatory and analgesic agent for topical drug delivery.
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