Abstract

This work has been carried out in order to investigate the possible ameliorative effect of Coriander seeds methanolic extract (CSE) on sodium arsenite (As) – induced toxicity in albino rats. 2,3 Dimercaptosuccinic acid (DMSA) was used as a standerd chelating agent. The experiment lasted for 8 weeks and blood samples were withdrawn 4 and 8 weeks after As and other treatments administrations. As was used to induce hepatotoxicity in rats in a dose equivalent to 100 p.p.m . In-vivo studies using the different biochemical techniques employed in hepato-renal functions as well as liver apoptotic DNA and total RNA alterations proved that As caused a significant increase in parameters concerned to hepato-renal toxicity while treatment of CSE or DMSA caused an ameliorative effect on this toxicity. Administration of CSE and DMSA together along with arsenite proves the synergistic effects of these chelating agents on arsenite toxicity.

Key words: Coriandrum sativum, Sodium arsenite, Hepato-renal functions, RNA and DNA fragmentation, Apoptosis.