Candida albicans is a very important organism in production of acute and chronic infections. It can be reason of serious infections in human immune compromised patients as nosocominal infections. In this study, We researched new anti-candida agents from Myrtus communis extracts by ASE (Accelerated Solvent Extraction). We were also determined Gallic, Ferulic, Quercetin phenolic compounds known charged with antimicrobial activity by HPLC (High-performance Liquid Chromatography). Gallic acid (2,424 mg/g) and Quercetin (2,289 mg/g) were detected in high amounts in Acetone extract and Methanol extract while Ferulic (0,018 mg/g; 0,038 mg/g; 0,006mg/g) was recorded in low amounts in Methanol, Ethanol and Ethly acetate extracts, respectively. Methanol, Acetone, Ethanol and Ethly acetate extracts showed good anti-candida activity against C. albicans, with Minimum Inhibitory Concentration (MIC) ranging from 0.187 to 1,5 mg/mL; Minimum Fungicidal Concentration (MFC) ranging from 0,375 to 3 mg/mL.
Key words: Candida albicans, Myrtus communis, ASE (Accelerated Solvent Extraction), Anti-candidal
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