Objective: Major depressive disorder (MDD) is a common psychiatric disorder. Irisin, produced by proteolysis of FNDC5, is thought to be an exercise-induced hormone that may play a critical role in inducing antidepressant-like effects. Our study aimed to investigate the relationship between irisin and newly diagnosed MDD patients.
Methods: This cross-sectional study included 85 first-time diagnosed MDD patients and 81 healthy controls. Patients were diagnosed with MDD using the Structured Clinical Interview Questionnaire for DSM-IV Axis I and II Disorders (SCID-I, II) and the Hamilton Depression Scale (HAM-D). After an overnight fast, 5 ml of peripheral blood was drawn and serum irisin levels were measured.
Results: When the effects of age and gender variables were controlled, no statistically significant difference in irisin levels was found between the groups. (F=1.832, p=0.178). When the effects of age, gender and body mass index variables were controlled and a partial correlation was made between irisin and HAMD scores, a significant negative correlation was found between irisin and HAMD scores (p
Key words: Major Depressive Disorder, Irisin, Etiopathogenesis
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