To prospectively evaluate the relationship between Mean Platelet Volume (MPV) levels and short-term mortality outcomes in critically ill patients aged ≥85 years. We hypothesized that abnormal MPV levels could offer actionable insights for predicting mortality risk in this highly vulnerable group, thereby improving therapeutic decision-making processes in the ICU setting. This study included patients aged ≥85 years. The participants were categorized into two groups based on their MPV levels at admission: group 1 (MPV≤12.5, normal range) and group 2 (MPV>12.5, elevated).A comprehensive set of variables, including demographic information, clinical indices, biochemical parameters, and respiratory metrics, were recorded. In a cohort of 475 participants, patients were stratified into two distinct groups based on MPV values: group 1 (n=400, 84.2%) and group 2 (n=75, 15.8%). The mean age was 89 (SD=7.7) and 88 (SD=6.2) years for group 1 and group 2, respectively, with a statistically significant difference (p=0.035). Significant differences were found in key biochemical parameters such as urea (p=0.045) and sodium (p=0.005). The most profound disparity was observed in platelet counts, with a highly significant p-value
Key words: Mean platelet volume, critical illness, morbidity, mortality risk, sepsis, systemic inflammatory response
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