Background. Some metal complexes of norfloxacin and ofloxacin have been synthesized and found to be more potent than their free ligands but have not been evaluated for their toxicities.
Objective. Effects of ofloxacin, norfloxacin and their metal complexes (nickel, copper and iron complexes) on kidney and liver function indices in rats were investigated. Methods. Ofloxacin and its metal complexes (2.86 mg/Kg body weight twice daily) and norfloxacin and its nickel complex (5.71 mg/Kg body weight twice daily) were orally administered to rats while the control animals received sterile distilled water for seven days. Afterwards, concentrations of selected serum electrolytes and biomolecules were determined.
Results. Ofloxacin significantly reduced (P
Key words: Fluoroquinolones, Cardiovascular, Kidney, Liver, Toxicity
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