Plants are still not only important in health care, but they are also the finest and safest hope for future medicine. These local ethnomedicinal plants discovered in Sikkim have been scientifically studied, and the results have been widely disseminated so that people can learn more about effective drug treatments and improve their health. The prevailing study focused on finding the maximum number of local ethnomedicinal plants found in the Sikkim Himalayan region with anticancer study. Published data in this review were all gathered from the online bibliographical databases: PubMed, Science Direct, Google Scholar, Research Gate, Cochrane, Core, and 1 Library. With the extensive literature review data, it was revealed that 77 medicinal plants found in the Sikkim Himalayan region have proven anticancer activity summarized in Table 1 by considering their local name (Nepali), part used for the treatment procedure, active extracts/study models (both in-vitro and in-vitro) and cell culture assay (diverse cell lines studies). Out of 77 selected ethno-medicinal plants, 27 were active in the in-vivo model, and the remaining 50 were active in the in-vitro model. As per the activity found in the active extracts, activity was highest in alcohol (methanol and ethanol extracts), followed by aqueous and ethyl acetate, chloroform, etc. Further research can be conducted on those plants that have shown the most promising anti-cancer efficacy in previous clinical tests, perhaps leading to low-cost plant-derived drugs to combat the expanding cancer epidemic.
Key words: Cancer, Cell Line, Medicinal Plant, Sikkim Himalayan Region
|
