Neonatal and obstetric outcome in systemic lupus erythematosus pregnancies at King Hussein Medical Center, Amman, Jordan

RMJ. 2014; 39(4): 449-451

Manal Al Mashaleh, Amer Gharaybeh, Abdallah Al Serhan, Kholoud Matar, Aysaylah Burgan, Osama Khataybeh, Ala' Al Heresh.

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Objectives: To study pregnancy outcome in women with Systemic Lupus Erythematosus looking for preterm delivery, growth restricted babies and the effect of SLE in developing pre-eclampsia. Methods: This study was conducted in collaboration between Rheumatology and Antenatal clinics. 500 pregnancies of healthy women labeled as group 1, and 49 pregnant women diagnosed to have SLE labeled as group 2. Birth weight, pre-mature labour pain and developing pre-eclampsia were looked for. Data were analyzed. Results: Women suffering from Systemic Lupus Erythematosus had more premature deliveries, (25% versus10%, OR 1.97). More growth restricted babies at ≤5th centile, (20% versus 5%, OR 2.87). SLE women were more prone to develop pre-eclampsia, (10% versus 2%, OR 5.36). Conclusion: Pregnant women with SLE bear higher risk for premature deliveries, growth restricted babies and higher rates of developing pre-eclampsia. Key words: SLE, Pre-eclampsia, Preterm labour, IUGR