Primary cutaneous diffuse large B-cell lymphoma NOS with short-term relapse
Salem A. Balhamar, Mohammed S. Alqarni, Abdulrahman N. Alotaibi, Abdulrahman M. Alkathiry, Areej M. Al Nemer, Osamah J. Refai, Ali M. Al-Amri.
Abstract
Primary cutaneous B-cell lymphomas are a unique, heterogeneous group of lymphoproliferative dis¬orders without evidence of extra-cutaneous manifestations. Primary cutaneous diffuse large B-cell lymphomas (PCDLBCLs) are aggressive neoplasms with poor prognosis. The infiltrate in some cases could involve the underlying subcutaneous tissues, but rarely reported. Accurate diagnosis is man¬datory as these patients respond well to systemic anthracycline-based chemotherapy (R-CHOP). In this article, we report a case of PCDLBCL/NOS that presented with skin manifestations and was diagnosed based on clinical features, pathology, and immunohistochemical staining. The patients were treated with systemic chemotherapy, CHOP-R, and responded well and the PET scan showed no evidence of residual disease after the 5th cycle. After 3 months of follow-up, the patient succumbed to his disease involving almost all his skin.
Key words: Lymphoma, DLBCL, Cutaneous, Relapse, Case Report
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