Abstract

This case report presents a unique and unreported association between synchronous hepatocellular carcinoma (HCC) and liposarcoma in a 30-year-old male petrochemical industry worker. The patient's main concerns were asymptomatic hyperferritinemia and isolated high gamma-glutamyl transferase levels. Clinical findings revealed mild hepatic steatosis, nonspecific nodular images, and fibrosis grade F4 on imaging and elastography. Further investigations confirmed the presence of HCC and subsequent liposarcoma in different organs. The patient underwent SIVB-VI hepatectomy followed by a nephrectomy to remove the tumors. The case report adds to the scientific literature by presenting a clinical scenario that has never been described before—the synchronous occurrence of HCC and liposarcoma in a patient with occupational risk exposure to aromatic organic compounds. The patient's occupation, along with other risk factors such as alcohol consumption, cirrhosis, and dyslipidemia, may have contributed to the development of these tumors. This report underscores the need for further research with larger sample sizes and extended follow-up periods to better understand the underlying mechanisms and outcomes associated with multiple primary neoplasms. The findings emphasize the significance of environmental and occupational chemical exposure as potential risk factors for developing HCC and numerous primary malignancies. Enhanced knowledge in this area can improve clinical understanding and inform optimal treatment approaches for patients with similar presentations.

Key words: Hepatocellular Carcinoma; Liposarcoma; Multiple Primary Malignancies; Case Report