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Original Research

RMJ. 2025; 50(1): 42-45


Efficacy of paroxetine with l-methyl folate and without l-methyl folate in the treatment of major depressive disorder

Ali Gul Tunio, Yasmin Shaikh, Daulat Ram, Ghulam Serwar Shaikh, Abdul Hameed Lanjwani, Faiza Shaikh.



Abstract
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Objective: To compare the efficacy of Paroxetine with and without L-Methyl folate in patients with major depressive disorder.
Methodology: A total of 160 major depressive disorder patients were divided into two groups with 80 patients in each group. All were treated with Paroxetine 20mg/day with L. methyl folate and without L. methyl folate for 2 months. All were examined clinically, and their demographic and medical history was recorded. Data were analyzed by SPSS 22.
Results: The symptom “sleep disturbance and weight gain improved significantly in treatment groups (p

Key words: Paroxetine, L. methyl folate, depressive disorder, MDD.





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03040506070809101112
2025

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