Background: infraorbital nerve block (IONB) is commonly used to enhance perioperative pain management in cleft lip surgery. We compared the addition of dexmedetomidine (DEX) or magnesium sulfate (MgSO4) to bupivacaine versus bupivacaine for IONB in combination with general anesthesia(GA) concerning the efficacy, duration of postoperative analgesia, and adverse events.
Methods: 75 patients, aged 3 months –7 years, of either sex, were randomly allocated into three equal groups after induction of GA to receive IONB either with (DEX +bupivacaine ) or (MgSO4 + bupivacaine ), and a control group received (bupivacaine only). The primary outcome was the length of time until the first analgesic was administered, while the secondary outcomes were the amount of acetaminophen taken overall in the first 24 hours following surgery, pain scores, and the frequency of side effects.
Results: Time to first requested analgesia was significantly longer in the DEX group, followed by the MgSO4 group, and shortest in the control group (Mean±SD, 13.9±1.7 h, 11.5±2 h, 5.9±1.3h respectively, P-value
Key words: Bupivacaine; Cleft lip; Dexmedetomidine; infraorbital nerve block; Magnesium sulfate
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