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Hexane fraction of Costus afer Ker Gawl leaves inhibited mitochondrial membrane permeability transition, F1F0 ATPase and scavenged nitric oxide and hydrogen peroxide

Godswill Nduka Anyasor, Funmilayo D Onajobi, Odutola Osilesi, Olugbenga Adebawo.




Abstract

Costus afer ker Gawl. is an indigenous medicinal plant used as therapy in the treatment of inflammatory disease such as rheumatoid arthritis. This study was designed to investigate the chemoprotective potentials of the hexane fraction of C. afer leaves (CAHFL) on some biochemical biomarkers such as mitochondrial membrane permeability transition (MPT), F1F0 ATPase, nitric oxide (NO•) and hydrogen peroxide (H2O2) activities using spectrophotometric methods. Results showed that isolated mitochondria fractions from normal rats preloaded with 10 - 60 μg/ml CAHFL significantly (P

Key words: Costus afer; mitochondria; ATPase; nitric oxide; hydrogen peroxide






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