Basal cell carcinoma (BCC) which is the most widespread malignant skin tumor around the world is an increasingly important public health problem since the incidence of BCC increases worldwide. In our study, we purposed to measure the variability of BCC invasion depth according to subtype, age, tumor diameter, gender, lymphocytic response, and anatomical localization and contribute to similar studies.100 BCC cases diagnosed in our department of pathology between January 2018 - June 2021 were included in the study. Clinicopathological parameters of the cases, such as demographic findings, tumor diameter, anatomical localization, histological type, and lymphocytic response, were obtained from the automatic data recording system of the hospital. The mean invasion depth was 3±1.87(0,5-13) mm. The relationship between depth of invasion and histopathological subtype (p=0.370), age (p=0.405), gender (p=0.937), lymphocytic response (p=0.418), and anatomical localization (p=0.118) was not significant. The depth of invasion was found to increase as the tumor diameter increases (p=0.004). A progressive increase in the incidence of BCC is noted making it an occupational and environmental disease with an obvious impact on the life quality of the patients. This puts a notable burden on the healthcare system, particularly in cases of invasive treatments and post-treatment relapses. Conducting multicenter research that investigates the efficacy of depth of invasion in different anatomical locations in a higher number of cases may help develop more effective treatments.
Key words: Basal cell, carcinoma, histopathologic subtype, invasion
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