Objective: Colon adenocarcinomas are the most common gastrointestinal tract malignancy and constitute one of the leading causes of mortality and morbidity worldwide. STAT3 is a transcription factor activated by many cytokines and growth factors and plays a crucial role in cell survival, proliferation, and differentiation. In this research, we aimed to elucidate the molecular properties of colon tumors.
Materials & Methods:A total of 196 patients with metastatic colon tumors whose samples were analyzed for KRAS, NRAS, and BFAF between 2016 and 2022 have been investigated in this retrospective study. The samples were analyzed via polymerase chain reaction(PCR)at our institution. STAT3 has been processed to all cases immunohistochemically, and staining intensities were graded.The results were compared with prognostic factors such as tumor molecular characteristics, lymph node status, grade, location, and diameter.
Results: A total of 196 patients, 79 (40.3%) female and 117 (59.7%) male, were included in the evaluation within the scope of the study. There was no significant difference between STAT3 staining intensities in terms of demographic characteristics. On the contrary, there was a statistically significant relationship regarding tumor grades (p
Key words: STAT3; RAF; RAS; colon carcinoma; mutation
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