Abstract

Bioactive compounds from microbial bioresources are among nature’s unprocessed chemical metabolites. These metabolites play a key function in creating inter-kingdom relationships. Scientists have been looking for bioactive metabolites with pharmacological activities in a variety of microbes over the last few years. Antibiotics, vitamins, antioxidants, enzymes, and anti-diabetics are all known to be found in microorganisms. The quantity and quality of microbial metabolites being evaluated have increased rapidly as a result of the development of high-throughput methods. According to some reports, microbial metabolites are much more effective in terms of effectiveness and potential for treating human diseases than their chemical counterparts. The present review deals with bioactive compounds producing microbes, their taxonomic diversity, various technologies for their extraction, the clinical status of these compounds, genomics and metagenomics-based approaches, and the biotechnological application of these compounds in healthcare.

Key words: Bioactive compounds, Genomics, Human health, Metagenomics, Microbes