The fourth deadliest reason for cancer-related deaths worldwide was found to be colorectal cancer (CaCo2). Zinc oxide nanoparticles (ZnO-NPs) have been researched for biomedical applications due to their demonstrated anticancer, antidiabetic, antibacterial, and anti-inflammatory. by way of the cytotoxic reactive oxygen species (ROS) that are produced when photosensitizers (PSs) are activated by light, which in turn cause cancer cell death, photodynamic treatment (PDT) causes selective cytotoxicity to malignant cells. The cytotoxic effect of different concentrations and wavelengths was studied on CaCo2, and the use of combination therapy to reduce the percentage of cell lines had clear effects on early apoptosis (p-value
Key words: Zinc-oxide nanoparticle, Diode laser, Combination therapy, Colorectal cancer therapy
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