Blood transfusion therapy is necessitated due to high amount of blood and fluid loss. Of recent, Veterinary hemotherapists have resorted to the use of haemaccel® and/or isoplasma® as whole blood substitutes in times of hemotherapy due to unavilabilty of whole blood or its components. However, there is dearth of information on their serum biochemical and electrolyte effects as reports emanating from their effects are that of human studies. Twelve healthy splenectomised Nigerian dogs were randomly assigned to 4 groups of 3 dogs each. Group A was untreated and served as control, group B received whole blood, group C received hemacccel®, group D received isoplasma®. On post surgical days (psd)- 14 and 21, the mean total plasma protein (TPP) of dogs in groups B, C and D were significantly (p
Key words: anaemia, blood, splenectomy, transfusion, isoplasma®, hemaccel®
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