Background: Pain is an unpleasant sensation, that has limitations with available drugs in terms of effectiveness and safety. Plant-based drugs have gained great importance due to their analgesic, anti-inflammatory and anti-pyretic ability, and limited side effects.
Aim and Objectives: The aim of the study was to evaluate the analgesic effect of Moringa oleifera (drumstick tree) and Tinospora cordifolia (guduchi) leaf extracts in rats.
Materials and methods: This prospective study consists 54 healthy Albino Wistar rats of male sex having weights ranging from 150 to 250 g. Normal saline as control and Tramadol was used as standard. Rats were randomly divided into nine groups (n = 6 in each). Commercially available M. oleifera leaf extracts and T. cordifolia leaf extracts were purchased to check the analgesic effect. Analgesic effect was determined by hot plate method after initial dose and by Tail-immersion method after 15 days of interval.
Results: The reaction time of AMO and ATC with doses 100 mg/kg, 200 mg/kg, 400 mg/kg was 4.28, 4.41, 4.74, and 3.96, 4.12, 4.22 at 90 min, respectively. While, tramadol showed high reaction time at 90 (6.41) and 120 min (7.17). The maximum analgesic effect was found at 90 min by hot plate and tail immersion methods in tramadol group than AMO and AMT.
Conclusion: The aqueous leaf extract of M. oleifera and T. cordifolia has similar analgesic properties. The study drugs have not showed any behavioral or lethal adverse effects during the study.
Key words: Pain; Moringa oleifera; Tinospora cordifolia; Analgesia
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