In this study, the protective roles of myricetin (MYC) and quercetin (QRS) against nephrotoxicity caused by malathion (MLT) intoxication were investigated. A total of 42 male rats were used and divided into 6 groups. The dose of MLT was fixed at 108 mg/kg/day and MYC or QRS were administered separately at doses of 100 and 200 mg/kg/day. All chemicals were orally administered for 28 days. At the end of the study, sera and kidney tissues were obtained. Serum urea, creatinine and uric acid levels, kidney malondialdehyde (MDA), nitric oxide (NOx), protein carbonyl (PCO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), prostaglandin E2 (PGE2), reduced glutathione (GSH), catalase, superoxide dismutase (SOD), glutathione redustase (GSH-Rx), glutathione peroxidase (GSH-Px), paraoxonase (PON), and arylesterase (ARE) levels were measured as well as histological examinations in kidney tissue were performed. MLT treatment increased serum urea and creatinine with increased levels of kidney MDA, NOx, PCO, 8-OHdG, PGE2 and decreased levels of catalase, SOD, PON, ARE, GSH, and GSH-Px in the kidney (p
Key words: Malathion, myricetin, quercetin, oxidative stress, inflammation, nephrotoxicity
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