Patients with diabetes mellitus often experience adverse complications, one of which is diabetic foot ulcers. Administering synthetic chemical drugs and physical treatment for wound healing and tissue regeneration deficiency in hyperglycemia is considered less effective and incurs high cost if long-term treatment is given. Ineffective therapy for diabetic foot ulcers carries the high risk of amputation and death. The development of plant-derived drugs is potential to discover effective, affordable, and safe therapy. Centella asiatica L. (C. asiatica) has wound-healing activities on the skin supported by its antibacterial, anti-inflammatory, antidiabetic, and antioxidant properties. Some of these pharmacological activities are expected to synergize in the healing process of diabetic ulcers. This review aims to reveal the supporting pharmacological activities of C. asiatica in wound healing which can be the basis for developing diabetic foot ulcer therapy. This study was conducted as a literature review through searches using the keywords "Centella asiatica", "wound healing", "antidiabetic activity", "antibacterial activity", and "antioxidant activity" from various journal articles in NCBI, PubMed, and other journal sources. The results show that C. asiatica has the potential to be developed for diabetic foot ulcer therapy with its supporting pharmacological activities, including the antidiabetic, anti-inflammatory, antioxidant, and antibacterial properties, which will improve its effectiveness in the wound-healing process.
Key words: Centella asiatica L, diabetic ulcer, wound healing
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