Abstract

New chelates complexes of general formulae [Cr(H2L)2Cl3.EtOH], [Fe(H2L)(OH)SO4(H2O).2H2O], [Fe(HL)2(OH)]. H2O, and [Co(H2L)(HL)2.1/2 EtOH] were prepared and identified by spectral techniques and thermogravimetric analysis Derivative thermo gravimetric analysis. The results confirmed that the ligand behaved as neutral tetradentate, bidentate, or monobasic tridentate. Coordination has occurred via carbonyl oxygen (C=O) and N(2)H or (C-S) groups in complex (3). Moreover, complex (3) was more stable than the analogs (1–3). The prepared mononuclear complexes exhibited an octahedral conformation. The ligand and Cr(III), Fe(III), and Co(II) complexes were investigated for their inhibitory action on the growth of Streptococcus pyogenes and Escherichia coli as Gram-positive and negative bacteria, respectively. The results indicated the effective behavior of Cr(III), Fe(III), and Co(II) complexes as being antibacterial compared to the ligand. The in vitro antitumor activity also displayed the potent action of compounds. In addition, it was revealed that the majority of complexes were more effective than their free ligand. Furthermore, molecular docking implementation demonstrated the intriguing possible interactions of the ligands and complexes with amino acid active sites of the ribosyltransferase moiety (PDB ID).

Key words: Complexes, thermal studies, antibacterial activity, antitumor activity, molecular docking