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Original Article

J App Pharm Sci. 2023; 13(11): 170-177


Synthesis, Mycobacterium tuberculosis H37Rv inhibitory activity, and molecular docking study of pyrazinamide analogs

Muhammad Zulqurnain, Nur Pasca Aijijiyah, First A. Wati, Arif Fadlan, Azminah Azminah, Mardi Santoso.




Abstract
Cited by 0 Articles

Pyrazinamide analogs 5a–h have been successfully synthesized by the Yamaguchi esterification method with yields ranging from 6% to 86%. Among pyrazinamides 5a–h, pyrazinamides 5d,g showed the best antituberculosis activity with MIC values

Key words: Pyrazine-2-carboxamides, Yamaguchi reaction, 2,4,6-trichlorobenzoyl chloride, antitubercular activity, molecular docking






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