Chondroitin sulphate is one of the glycosaminoglycans (GAGs) generally acquired from animal tissues. CS has an anti-inflammatory, anti-apoptotic and antioxidant properties. The GAGs have been recently reported to possess the ability to influence oxidative stress known to lead to free radical mediated biological damage. Herein, we report the effect of some GAGs on superoxide dismutase (SOD) and xanthine oxidase (XO) activities in experimental animal models submitted to osteoarthritis surgery. In this respect, SOD and XO activities were investigated in New Zealand rabbits treated with different types of glycosaminoglycans (GAGs); commercial chondroitin sulphate (CCS) and bacterial chondroitin sulphate (BCS) (produced by using E. coli). The results of this study revealed that both CS sources significantly (P
Key words: Glycosaminoglycans, superoxide dismutase and xanthine oxidase activities, animal models, commercial and microbial chondroitin sulphate.
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