The study aimed to determine the effect of S. cerevisiae and L. acidophilus as probiotics against S. Typhimurium isolated from poultry, for this purpose (50) fecal samples were collected from poultry to isolate S. Typhimurium, while fermented milk was used for isolation of Lactobacillus acidophilus. Results of the current study showed that S. Typhimurium was isolated at a rate of 6%. The in-Vivo adhesion Index test showed a high ability of L. acidophilus to adhesion to rat intestine endothelium in compare with Saccharomyces cerevisiae. The inhibitory zone occurred by S.cerevisiae filtrate, L. acidophilus filtrate, (S .cerevisiae and L. acidophilus mixture) filtrate were (10, 16, 19 mm) respectively. The results of the experimental study showed the high activity of (S.cerevisiae and L. acidophilus mixture) filtrate in protecting experimental animals. The main pathological change that occurred by S.typhimurium was the infiltration of inflammatory cells.
Key words: probiotic, S. typhimurium, poultry
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