Hepatoprotective effect of pycnogenol in gentamicin-induced liver injury in rats
Tuba Ozcan Metin.
Abstract
Aim: The present study aimed to investigate the possible hepatoprotective effect pycnogenol (PYC) in gentamicin (GEN)-induced liver injury in rats.
Materials and Methods: The study consisted of four groups of seven rats; control, PYC (20 mg/kg for 8 days), GEN (80 mg/kg for 8 days) and GEN+PYC. At the end of the experiment, liver tissues of all groups were collected for histopathological and immunohistochemical (fibrillin-1, caspase-3, and betatrophin antibodies) evaluation.
Results: Histopathological analysis revealed that the GEN treated group had liver damage as a result of the GEN administration compared to the control group. Additionally, fibrillin-1, caspase-3, and betatrophin expression all increased in rat liver tissues. However, PYC pretreatment significantly reduced the expression of the aforementioned antibodies and mitigated liver damage.
Conclusion: The anti-apoptotic and antioxidant properties of PYC may help to preserve liver histoarchitecture against GEN-induced hepatotoxicity.
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