Abstract

Objective: This study aimed to determine the association between the time of anticoagulant administration and the outcome of patients with the acute coronary syndrome (ACS).
Methods: This was a single-center retrospective cohort study of adult patients diagnosed with ACS in the emergency department at King Abdul-Aziz University Hospital (KAUH) in Jeddah between January 2015 and December 2020. The data were obtained from the medical records of the KAUH, and through Google forms.
Result: Of 206 patients, using a cutoff of 4 hours, 55 patients (26.5%) were classified into the early treatment group, whereas 152 patients (73.4%) were in the non-early treatment (>4 hours) group. In the final analysis, the non-early treatment group had a higher mortality rate compared with the early treatment group (4.6% vs. 3.6%, p < 0.01) but had a lower risk for intracranial bleeding compared with the early treatment group (0% vs. 1.8%, p < 0.01).
Conclusion: It was demonstrated that lower rates of mortality were correlated with the early administration of treatment in ACS. A 3.6% mortality rate had declined in patients who received early treatment in comparison with the 4.6% mortality rate in patients who had not received treatment early. This emphasizes how early therapy is effective and essential in enchasing and improving quality and overall patient health and life. Thereby, motivating early interventions in hospitals.

Key words: acute coronary syndrome, anticoagulant therapy, mortality, ST segment elevation myocardial infarction, timing