Objective: The objective of the present study is to investigate the analgesic activity profile of xanthium strumarium Linn. (Family: Asteraceae) in mice and rats, using various models. Materials and Methods: The effects of the butanolic extract were observed in three different dose levels 50, 100, and 150 mg / kg, as the extract did not show any sign of toxicity up to 500 mg / kg (p.o.) dose. The investigation was carried out for assessing the activity on thermal and chemical-induced pain reactions. Result: The Xanthium strumarium (XS) fruit's butanolic extract did not have any significant effect on the thermal pain reaction (hot plate method). The extract was devoid of any protective effect against acetic acid-induced writhing, at any of the tested doses. Conclusion: The Xanthium strumarium Fruits' butanolic extract lacked analgesic activity.
Analgesic, acetic acid, investigation, writhing