In the era of the Covid-19 pandemic, which affected 211 countries on 6 continents, researchers and clinicians focused mainly on the most detailed understanding of the new virus and possibilities for its elimination. The interest in the mechanisms of development of resistance of pathogenic microorganisms to commonly used antibiotics, observed for many years, has slightly decreased. Regardless of the situation, the problem of infections with multidrug-resistant Gram-negative microorganisms has not diminished in recent times. Due to overloaded health systems, crowded hospital wards and overworked staff, its importance has even increased. Patients infected with the Wuhan virus or during convalescence, often older and with impaired immunity are even an ideal reservoir for mutant bacterial strains. In this short review, the authors wanted to include and briefly summarize the current knowledge of NDM-producing microorganisms, mechanisms of their resistance to antibiotics, current therapeutic regimens in an attempt to assess their effectiveness, and summarize the directions of research that are and will probably continue to be carried out on new antibacterial drugs.
Key words: Klebsiella pneumoniae, hospital aquired infections, metallobetalactamases, antibiotic resistance, antibiotic stewardship
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