Marine-derived fungi have been evident sources of new secondary metabolites with an incredible diversity of structural and bioactivity. The accretion of research into discovering new secondary metabolites from marine-derived fungi has continued upward over the last few years. Marine-derived fungi have been found and isolated from various marine habitats, including sponges and algae. This review report displays the structures of new compounds isolated from algae-derived and sponge-derived fungi and their activities, covering the literature from 2017 to 2021. A total of 339 new compound structures were reported in this study, of which 169 compounds were distributed from algae-derived fungi and 170 were isolated from sponge-derived fungi. The compounds distributed were classified as alkaloids, aromatics, lactones, peptides, polyketides, pyrones, steroids, and terpenes isolated from Trichoderma sp., Aspergillus sp., Penicillium sp., Alternaria sp., Talaromyces sp., Acremonium sp., and Pestalotiopsis sp. Based on activity, these compounds have various activities such as antibacterial, cytotoxic, antioxidant, antifungal, anti-inflammatory, and butyrylcholinesterase inhibition. Several compounds showed stronger activity than the control. In the end, a review of this report can provide information on the great potential of discovering and developing new compounds to be used as led compounds derived from marine fungi.
Key words: marine-derived fungus, sponge-derived fungus, marine fungi, natural products, bioactivities
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