STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3
Audia Triani Olii, A.K. Nugroho, Ronny Martien, Sugeng Riyanto.
Abstract
This study aimed to determine the stability of niosome vitamin D3 at two different temperatures, room temperature 25oC and 4oC, and to view the in vitro release profile and determine the kinetics model of the release. Niosome is a drug delivery system formed from surfactants and cholesterol in the form of vesicles that entrap drugs in their matrix. This allows the drug trapped in the niosome matrix to be protected from the influence of the biological environment, which can reduce or eliminate drug activity. In addition, in the presence of a vesicle matrix system, it often provides a modified release. From a previous study conducted by Audia et al., vitamin D3 niosome were prepared from Span 60 and cholesterol using the thin layer method. In this study, a stability test was carried out for 30 days at two different storage temperatures, as well as an in vitro study of the release of vitamin D3 niosome to determine the release kinetics model. The results showed that vitamin D3 niosome were more stable at 4oC than at 25oC. The in vitro release test showed the release of vitamin D3 niosome at 3.25 ± 0.2% for 420 minutes with release kinetics following the Korsmeyer-Peppas kinetic model.
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