Objective: To the assessment of Apolipoprotein E genetic polymorphism variations (E2/E3, E3/E4, E3/E2, E2/E4, E2/E2, E4/E4) and correlation with anti-cyclic citrullinated peptides (ACCP) antibodies in Iraqi patients with rheumatoid arthritis.
Methods: A case-control study was conducted at the rheumatologic outpatient department at Baghdad teaching hospital and included forty-five patients with rheumatoid arthritis (seven male and 38 female) enrolled in the study. APOE and ACCP levels were estimated by ELISA. RT-PCR was used to investigate APOE SNP (rs7412 and rs429358).
Results: The results of this study reveal the statistical difference in the level of Apo E between the patients and the control group. The mean of the APOE in the patient's group compared to the control group (p-value
Key words: Rheumatoid arthritis, APOE, ACCP, SNP
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