Abstract

Aim: Elderly patients frequently require surgery. Postoperative cognitive dysfunction (POCD) is an adverse event and reduces the patient’s quality of life. We aimed to compare the effects of sedation applied with propofol or propofol-ketamine (ketofol) combination on hemodynamics and POCD during spinal anesthesia in elderly patients undergoing urological surgery.
Materials and Methods: Study was performed on 60 ASA I-III patients over 65 years of age. Before the operation (standardized Mini Mental Test) sMMT was applied by a blind researcher. The cases were randomly divided into two groups as propofol (Group P, n=30) and ketofol (Group K, n=30). ECG, SpO2, Bispectral Index (BIS), noninvasive blood pressure (NIBP) was monitored. After spinal anesthesia, group P received propofol 0.5 mg/kg IV bolus and then 1.5 mg/kg/hour infusion. Group K received propofol 0.4 mg/kg and ketamine 0.1 mg/kg IV bolus and then propofol 1.2 mg/kg/hour and ketamine 0.3 mg/kg/hour infusion. Hemodynamic and respiratory data were recorded. The sedation level was monitored by RAMSAY sedation score. sMMT was repeated by the researcher who performed the initial test at postoperative first 24 hours and postoperative 3rd day.
Results: Significant decreases were observed for heart rate, SAP, and MAP in both groups compared with baseline values. No statistically significant difference was detected between the groups in sMMT values at postoperative 1st and 3rd days. Within-group comparisons revealed significant differences between preoperative sMMT and postoperative 1st day sMMT and between postoperative 1st and postoperative 3rd day sMMT (p< 0.001). No difference was detected between preoperative and postoperative 3rd day sMMT (p< 0.25). In Group P, there was statistically significantly higher injection pain (p

Key words: Cognitive dysfunction; elderly patient; ketamine; propofol; spinal anesthesia