Abstract
Background: This study involves the use of a new multifunctional prosthetic mesh for treatment of perineal without complications. The prosthetic mesh is a hybrid platform of both synthetic and natural materials with its backbone consisting of a synthetic commercial polyester fabric (CPF) to deliver the required mechanical integrity. The CPF mesh was coated by a natural biodegradable, biocompatible and antimicrobial layer of chitosan (CS) incorporating phenytoin (PH)-loaded pluronic nanomicelles for healing promotion, and ciprofloxacin (CPX)-alginate polyelectrolyte complex-based microparticles as antibacterial agent.
Aim: The aim this study is to evaluate the new developed multifunction polyester-based hybridmesh to repair perineal hernias clinical cases in dogs.
Methods: The used multifunctional prosthetic mesh is a hybrid of the natural biodegradable, biocompatible and antimicrobial materials was used in 6 case of perineal hernia
Results: The prosthetic polyester-based hybrid mesh was found very helpful for repairing clinical cases of perineal hernias in 6 dogs without unwarranted other surgical procedures or complications. The developed mesh proved its feasibility in terms of efficient biocompatibility, stability, sterilizability and low cost.
Conclusions: The prosthetic commercial polyester-based mesh provided the ideal and feasible alternative prothesis with many advantages
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