Nebivolol hydrochloride (NBH) chitosan-PLGA loaded nanoparticles obtained using the nanoprecipitation/solvent
displacement process in the present study, characterization by P-XRD, DSC, SEM, and FTIR analytical techniques. During the invitro drug release, ex-vivo permeation studies. The nanoparticles prepared to employ 150mg chitosan, 100mg PLGA, and 1:5 H2O:
CH2Cl2 incorporated with NBH showed a high drug entrapment of approximately 94%, with an average particle diameter of 180.32
nm and zeta potential of −30.40±0.12 mV. The nanoparticles exhibited a sustainable drug release when studied for 60 minutes. The
nanoparticles mentioned above were later formulated into a nanogel with the help of Carbopol 934 for transdermal application and
subjected to ex-vivo permeation studies for 12 hours on excised rat’s skin. The optimized formulation subjected to studies in rats
showed a considerable enhancement in bioavailability (3 folds) compared with the NBH oral suspension.
Key words: Nebivolol hydrochloride, Nanoparticles, Carbopol 934, Nanogel, Bioavailability
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