Abstract

Objective: To evaluate the oxidative stress markers in fiber glass workers occupationally exposed to lead.
Methodology: This cross sectional study included 50 workers of fibre glass industry with an age range of 25 to 40 years and duration of working greater than five years. We used probability sampling methods. Heavy smokers, subjects with a family history or personal history of respiratory pathologies were excluded from the study. Twenty ages matched individual with no history of any disease were taken as control from local community. Duration of study was March to May 2017. The circulating levels of lead, superoxide dismutase (SOD) and of Malondialdehyde (MDA) were measured by standard procedures.
Results: Mean age of workers and control was 35 and 33 years with BMI 23 and 24 Kg/m2, respectively. The average working duration was 6-7 years. Level of serum lead was significantly increased in workers in comparison to controls. In response to high level of lead (fiberglass lead wires) the level of antioxidants like SOD and MDA were also high in comparison of their control.
Conclusion: A significant increased level of circulating lead in workers of fiberglass factory causes increased values of oxidative stress markers (superoxude dismutase and malondialdehyde) in their blood, which may be harmful for their health.

Key words: Lead, antioxidants, fibre glass workers, MDA.