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Case Report



The use of selective arterial calcium stimulation test in the diagnosis of the hyperinsulinemic hypoglycemia

Yasemin Aydoğan Ünsal, Özen Öz Gül, Soner Cander, Coşkun Ateş, Ensar Aydemir, Oktay Ünsal, Canan Ersoy, Erdinç Ertürk.




Abstract

We examined the patients with hyperinsulinemic hypoglycemia who were performed non-invasive imaging techniques with doubtful or failed results. We compared the performances of the Selective Arterial Calcium Stimulation Test (SACST) and non-invasive imaging techniques. Eight patients with hyperinsulinemic hypoglycemia, performed SACST after evaluating with imaging modalities were examined retrospectively. Three patients were diagnosed with Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS), 4 with insulinoma, and 1 with autoimmune hypoglycemia after SACST. While the concordance between the SACST and surgery-proven pathology for insulinoma was 50% (2/4), the accuracy in the localization of insulinoma was 25%. Although SACST does not have high concordance with surgery-proven pathology and accuracy in the localization of insulinoma, it may be preferred in the differential diagnosis of hyperinsulinemic hypoglycemia in medical centers where other imaging techniques are not available, or in cases where other imaging methods obtain suspicious/inadequate diagnosis.

Key words: Hyperinsulinemic hypoglycemia, insulinoma, non-insulinoma pancreatogenous hypoglycemia syndrome, selective arterial calcium stimulation test






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