Sepsis is one of the most serious problems in intensive care units due to its high morbidity and mortality. Objective of the study to compare the healing effects of Activated Protein C and Tri-Iodothyronine in the late period of experimental sepsis. Twenty-four Wistar Albino male rats were divided into 4 groups, including the control group, septic group, Activated Protein C (APC), and Tri-Iodothyronine (T3) treatment groups. Leukocyte, thrombocyte, IL-1, IL-6, TNF-α, and antithrombin-III levels were investigated. Histopathological evaluation was performed by taking the liver, lung and intestinal tissue samples. The APC and T3 replacement groups were compared with the septic rat group, and it was observed that they preserved thrombocyte levels and antithrombin III levels, suppressed interleukin levels, and limited the effects of inflammatory responses in the liver, intestine and lung tissue. Leukocyte levels were found to be significantly higher in the T3 replacement group than in the septic group, while there was no significant difference between the APC group and the septic group. Our study showed that both activated protein C and Tri-iodothyronine can be effective in the host's response to infection in the late period of sepsis, alone and in a single dose.
Key words: Sepsis, activated protein C, tri-iodothyronine, cecal ligation and puncture, proinflammatory cytokines, antithrombin III
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