Abstract

This study was done to investigate the prevention of ethanol-induced ulcer of Eurycoma longifolia (E. Longifolia). E.
longifolia aqueous extract was obtained from a commercialised product (Nu-Prep Lelaki). A total of 36 rats (n=6 for each group)
which were separated into 6 groups were used in the present study. All rats were fasted from food for 24 hours prior to the pretreatment. For pre-treatment, Group 1 (normal group) and Group 2 (negative control group) received 0.9% normal saline, Group 3
(positive control group) received 150 mg of ranitidine, Group 4 (low dose group), Group 5 (intermediate dose group) and Group 6
(high dose group) each received 250 mg/kg, 500mg/kg and 1000mg/kg of E. longifolia respectively. Rats from Group 2, Group 3,
Group 4, Group 5 and Group 6 were induced with ulcers by administration of 5 ml/kg of absolute ethanol an hour after the pretreatment. The rats were euthanized an hour after ulcer induction. The stomachs were weighed and the degree of ulcerations was
scored. The mean ulcer score for Group 2 was found to be the highest (3.83) followed by Group 4 (1.83), Group 3 (1.5), Group 5
(0.83), Group 6 (0.33) and Group 1 (0). The mean ulcer score of Group 2 is significantly higher (p

Key words: Eurycoma longifolia, E. Longifolia, gastric ulcer, peptic ulcer, ethanol-induced ulcer, anti-ulcer effects, protective effects against ulcer