Aims: The study was conducted with an aim to assess the diagnostic importance of bone marrow aspirate and biopsy examination to reach the final diagnosis in clinically diagnosed and undiagnosed cases of both haematological and non-haematological disorders.
Methods and Material: A prospective study was conducted to correlate the findings of bone marrow examination with clinical parameters. The study included 42 patients, in whom bone marrow evaluation was carried out in the form of bone marrow aspirate and marrow biopsy. Cases, where both aspirate and biopsies were inadequate for opinion, were excluded from the study.
Results: A total of 42 cases were studied after excluding inadequate samples. The majority of cases were in the age group 30 to 50 years, with male preponderance. The most common finding was nutritional anaemia; the features of both megaloblastic and iron deficiency anaemia were seen in 38.1% of cases; iron deficiency was seen in 11.9% cases and 7.1% cases showed megaloblastic anaemia. Leukaemia (both acute and chronic) were seen in 4.8% of the cases. Other cases were necrotizing granulomatous inflammation of bone marrow, aplastic anaemia, metastasis to bone marrow, plasma cell dyscrasias, ITP, the gelatinous transformation of marrow, hemophagocytic lymphohistiocytosis, congenital dyserythropoietic anaemia and myelofibrosis etc.
Conclusions: The correlation of morphological findings of bone marrow aspirate and biopsy with other clinical and pathological features can aid in the diagnosis of cases that have been missed clinically.
Key words: Bone marrow aspirate, bone marrow biopsy, marrow diseases
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