Abstract

Objective: To assess the hepatoprotective effects of Ivy leaf extract in order to overcome the hepatotoxicity induced by isoniazid in rabbits.
Methodology: This analytical experimental study was carried out at animal house in the Department of Pharmacology, Karachi University. The duration of the study was 60 days. A total of 30 healthy rabbits were divided randomly into three equal groups. Group I or control group, group II isoniazid (INH) group while in group III combined effects of isoniazid and Ivy leaf extract. Serum alanine transaminase (ALT) level was measured. ANOVA test followed by post hoc multiple comparison was applied to assess the difference between the groups.
Results: There was significant difference in the mean level of ALT at Day 7 between the groups (p=0.001). A significant difference was observed between the groups at day 30 and 60 (p

Key words: Hepatotoxicity, isoniazid, serum glutamate oxaloacetate transaminase, SGOT.