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Coagulation profile in pathophysiology of sickle cell anemia

Shehin M, Kanhu Charan Purohit, Sunil Kumar Jena, Basila V.


Background: Sickle cell anemia (SCA) is an emerging public health challenge in India as well as globally. The WHO recognized it as a global problem since long time. In Western Odisha, its prevalence varies from 5% to 30%.

Aim and Objective: The objective of this study was to determine the alteration of the coagulation profile in SCA in comparison to healthy control.

Materials and Methods: This study was completed with 60 subjects that included 30 cases and 30 controls. This study was approved by the Institutional Ethical Committee. The hematological parameters such as bleeding time, clotting time, total platelet count, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were tested. The data were analyzed through SPSS 20.

Results: In this study, it was found that patients with SCA have increased clotting time (P = 0.007), PT (P = 0.000), aPTT (P = 0.003), and total platelet count (P = 0.183), but decreased bleeding time (P = 0.000) in comparison to healthy control.

Conclusion: We found a significant increase in clotting time, PT, and aPTT, but decrease in bleeding time in SCA patients in comparison to healthy adults.

Key words: Coagulation profile; Sickle cell anemia; Hypercoagulability

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