Staphylococcus aureus, Escherichia coli, and Candida albicans are opportunistic species responsible for clinical infection by producing biofilms. In the form of biofilm, they are more resistant to various antimicrobial agents. This study at to determine the biofilm activity of onchidiid slug extract against S.aureus, E.coli, and C.albicans. The microtiter broth method was used to measure the inhibitory and eradicating ability of S.aureus, E.coli, and C.albicans biofilms. In samples of onchidiid slug ethanol extract at a level of 1%, the S. aureus biofilm was inhibited by 63.89%. The MBIC value is at a level of 0.5%. The inhibitory activity on E.coli biofilm was 85% at 1%, with the MBIC value at 0.5%. Onchidiid slug ethanol extract samples also showed inhibitory activity on the C.albicans biofilm of 67.95% at a level of 1% with an MBIC value of 0.25%. The test results showed that extract could be developed as a new antibiofilm candidate for treating S.aureus, E.coli, and C.albicans biofilm infections.
Key words: Onchidium typhae, antibiofilm, Onchidiid slug extract ethanolic
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