Abstract

Objective: To determine common coagulation disorders like abnormal prothrombin time/ international normalized ratio (PT/INR) abnormal activated partial thromboplastin time (aPTT), and decreased platelets count in patient with chronic liver disease (CLD).
Methodology: This study included 278 patients with CLD at Bilal Medical Trust and Hospital (BMTH) Pir Baba from January to October 2019. Bloods sample were collected in Ethylene diamine tetra acetic acid (EDTA), sodium citrate and plain vacutainer for Platelet’s count, PT and aPTT. These tests were performed using hematology and coagulation analyzers respectively. PT ratio was calculated along with INR ratio.
Results: Out of 278 patients, 23 (8.3%) had normal PT (less than 15 seconds), while 255 (91.7%) had prolonged PT (more than 15 seconds). aPTT were prolonged in 245 (88%) patients. 236 (84.89%) patients had both prolonged PT and aPTT. While 164 (64%) patients had low platelets count.
Conclusion: Most of the cirrhotic patients (more than 90%) were having abnormal pictures of the coagulation and even disturbed counts of low platelets.

Key words: HCV, Coagulation, PTAPTT, platelets, Bunir.