This study was dealt with evaluation of antibacterial effectiveness of each (Azithromycin, Chloramphenicol
Gentamacin, Levofloxacin and Ciprofloxacin) computationally as antibacterial agents. This study was conducted by
computational methodologies ‘In silico’. The 3 dimensional (3D) structure model of DNA gyrase enzyme of Staphylococcus
aureus was built by Homology Modeling method as target protein and the active site was visualized. The computational
prediction showed molecule (Levofloxacin and Ciprofloxacin) has highest binding score (-45 Kcal/mol) ( -40 Kcal/mol)
respectively with active site of target protein and molecules (Azithromycin) binding score were (-12 Kcal/mol) meanwhile
molecule (Gentamicin and Chloramphenicol) showed lowest binding score (-10 Kcal/mol) (-8 Kcal/mol) respectively with target
DNA gyrase of Staphylococcus aureus bacteria .
Key words: Staphylococcus aureus, DNA gyrase, Antibacterial agent, computational study
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