Reactive thrombocytosis post splenectomy is usually self-limiting. Hence in patients with raising platelet count after splenectomy detailed evaluation may be required to rule out other causes of thrombocytosis. Extreme thrombocytosis(>10 lakhs/cmm) leading to thrombotic or hemorrhagic complications can be multifactorial i.e., Infection, iron deficiency, Myeloproliferative disorders - CML, Polycythemia vera, essential thrombocytosis. Timely treatment of patients with thrombocytosis can prevent the development of life-threatening complications like splenic, mesenteric, and portal vein(PST-SMPv) has an incidence of 8%-10%, splenic size and myeloproliferative disorders are the main risk factors. Here we index an unusual case of reactive thrombocytosis post-traumatic splenectomy in which extreme thrombocytosis had to be controlled with systemic anticoagulation
Key words: Splenectomy, thrombocytosis, JAK 2 mutation
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