Objective:Fentanyl is one of the opioids commonly used in the induction of general anesthesia and can cause coughing. The cough that occurs can be a problem in patients where it is necessary to avoid pressure increase. This study aimed to determine the incidence of fentanyl-induced cough (FIC) and the difference between the doses used.
Method: This prospective randomized placebo-controlled trial included 750 ASA I-II patients aged 18-65 years who underwent elective surgery under general anesthesia. The patients were randomly divided into three groups. 1 µg kg-1 fentanyl was used to induce the patients in Group 1, and 2 µg kg-1 fentanyl was used for the induction of the patients in Group 2. In the installation of patients in Group K, the control group, fentanyl was not used, and a placebo was administered. All patients were observed for 60 seconds after fentanyl injection. The cough severity (mild: 1-2, moderate: 3-4, severe: >5 times) and time of cough and demographic data of the patients were recorded and compared.
Results: Demographic data were similar between groups. Cough was observed in 15 patients (6%) in Group 1 and 80 patients (32%) in Group 2. Incidences of FIC were 6%, 32%, and 0% in Groups 1, 2, and K, respectively. While all of Group 1 was mild, 82% of the cough observed in Group 2 was mild, and 18% was moderate. The incidence and severity of cough in Group 2 were significantly higher than in Group 1 (p
Key words: Fentanyl, cough, general anesthesia
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