A case-control study include 60 patients with beta-thalassemia major type with recurrent blood transfusion were visited
Babylon center of hereditary blood disorder in Babylon teaching hospital for maternity and children and 60 individuals
who seemed to be healthy. This study aimed to assess N-acetyl-beta-glucosaminidase and others renal function and
to look for renal complications in those patients if any. These patients and control groups divided into two subgroups
according to age, group I were less than 18 year and group II were equal or more than 18 years. The present study’s
findings showed that there was a significant difference in the levels of Albumin to creatinine ratio, Beta2-microglobulin,
N-Acetyl beta-D-glucosaminidase, serum creatinine level, and blood urea between patients group and its healthy group
(p < 0.05). In conclusion, beta-thalassemia major patients frequently have renal hemosiderosis and asymptomatic renal
impairment, which are not found in routine renal investigations, it needs regular checks for early detection of tubular
and glomerular failure
Key words: Beta 2 microglobulin ACR NAG,Renal hemosiderosis,Thalassemia major
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