Objectives: The aim of our study was to assess the alterations in serum C-reactive protein (CRP) values in patients with chronic venous
insufficiency (CVI).
Patients and methods: Between June 2013 and November 2013, a total of 100 consecutive patients (50 males, 50 females; mean age 42±13
years; range, 21 to 61 years) who were admitted to the outpatient clinic with pain, prickle, paresthesia or night cramps were included in
this study. The patients were divided into two groups. Varice group (n=50) consisted of isolated CVI patients (primary CVI) with a family
history of varices and without a history of deep venous thrombosis. Non-varice group (n=50) consisted of patients who underwent non-venous
pathologies-related surgical interventions previously or had no prior history of surgery. All patients underwent lower limb venous Duplex
ultrasound examination bilaterally. Serum CRP and complete blood count examinations were performed and white blood cell (WBC) levels
were assessed.
Results: There was no statistically significant difference between the varice group and non-varice group in terms of the mean CRP values
(3.80±1.47 mg/L vs 4.74±3.86 mg/L, respectively; p=0.983). However, the mean WBC levels were statistically and significantly different
between the groups (6966±1943/µL for varice group vs 8528±2767/µL for non-varice group, respectively; p
Key words: C-Reactive protein; inflammation; varice; venous insufficiency.
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