Activation of Complement, In Suture and Prosthetic Graft Materials
M. Behçet Sevin, Sadettin Dernek, Bülent Tünerir, İslam Kaklıkkaya, Tuğrul Kural, Recep Aslan.
Abstract
The determination of the graft material that is least succeptible to graft rejection due to Complement system activa- tion in synthtetic vascular grafts and suture materials.
Blood samples have been taken out from 20 persons. Sera were extracted, and cach sample was devided into 7 seperate tubes. In the first one used a control to vascular check the complement levels, in other tubes PTFE vascular graft, Dacron vascular graft, PTFE together with polypropylene suture, Dacron graft with PTFE suture and polypropy- lene suture samples were put. Following one hour incubation complement (C3e) and C, levels were measured.
As compared with the control group, there was complement activation in the following 6 tubes, (p< 0.001). Comple- ment activation in Dacron graft and polypropylene suture combination was the gretest of all. Increase in the trombo- cyte and polymorphonuclear leukocyte activity and aggregation may results in early or late graft failure. We believe that attempts to avoid the compliment activation will pre-early or late phase graft failure.
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